Home Overview Research Programs Shared Facilities News & Outreach Technology Transfer Employment About PHRI

 
Scientific Overview Research Interest Summary Principal Investigators    Yuri Bushkin, Ph.D.
   Theresa Chang, Ph.D.
   Neeraj Chauhan, Ph.D.
   Véronique Dartois, Ph.D.
   Karl Drlica, Ph.D.
   David Dubnau, Ph.D.
   Eliseo A. Eugenin, Ph.D.
   Marila Gennaro, M.D.
   Gilla Kaplan, Ph.D.
   Fred Kramer, Ph.D.
   Barry Kreiswirth, Ph.D.
   Min Lu, Ph.D.
   Leonard Mindich, Ph.D.
   Arkady Mustaev, Ph.D.
   Jyothi Nagajyothi, Ph.D.
   David Perlin, Ph.D.
   Richard Pine, Ph.D.
   Abraham Pinter, Ph.D.
   Marcela Rodriguez, Ph.D.
   Selvakumar Subbian, Ph.D.
   Sanjay Tyagi, Ph.D.
   Christopher Vinnard, M.D.
   Chaoyang Xue, Ph.D.
   Xilin Zhao, Ph.D.

   Research Faculty
   Liang Chen, Ph.D.
   Eugenie Dubnau, Ph.D.
   Jeanette Hahn, Ph.D.
   Salvatore Marras, Ph.D.
   Lanbo Shi, Ph.D.
   Yanan Zhao, Ph.D.

Emeritus Faculty Recent Publications
 
Jyothi F Nagajyothi, Ph.D.

Research Summary  |  Selected Publications  |  C.V.
 

Public Health Research Institute Center
at the International Center for Public Health
New Jersey Medical School - Rutgers, The State University of New Jersey
225 Warren Street
Newark, New Jersey 07103, USA

Phone: (973) 854-3450
Fax: (973) 854-3201
e-mail: JFN31@njms.rutgers.edu



Research Summary

Lipid induced metabolic disorders and chronic infectious diseases

Chagas disease, caused by Trypanasoma cruzi, is a chronic infectious disease that represents the third greatest tropical disease burden after malaria and schistosomiasis. A major complication of Chagas disease is Chagasic cardiomyopathy (CCM), an important cause of congestive heart failure in the endemic regions of Latin America. The pathogenesis of Chagas disease needs to be considered in the context of the endemic regions, where there is an increase in obesity, diabetes, hypertension and chronic cardiovascular disease.

My research has identified a strong link between T. cruzi invasion and cardiac lipid homeostasis in CCM. Whole body lipid homeostasis depends on many organs and signaling pathways, among them adipocytes, pancreas and liver play major role in lipid metabolism especially during T. cruzi infection. Another important factor is diet, which also regulates the outcome of T. cruzi infection. Current research in my laboratory is focused on establishing the link between Chagas disease and metabolic disorders. The effect of different lipid and glucose lowering drugs such as Lipitor and Metformin, respectively, on different stages of CD in murine model is being studied. Our data suggest that CCM is the result of two distinct perturbations in lipid metabolism: an increase in lipolysis and lipid influx to the myocardium during acute infection; and an induction of de novo lipogenesis in the myocardium during the intermediate (latent) stage of infection. Diet, a major regulator of adipogenesis plays a significant role during infection. Our studies target this novel pathogenic mechanism to understand the link between acute infection induced lipid metabolic disorder and chronic chagasic cardiomyopathy. My research is focused on four interlinked areas:

1) Role of diet in the development of metabolic syndrome in chronic infectious diseases
2) Parasite host adipocyte/adipose tissue interaction and the pathogenesis of infectious diseases
3) Role of serum lipoproteins in the pathogenesis of Chagas heart disease
4) Adipocyte, pancreas and liver malfunction during acute and chronic infections and its consequence on the development of metabolic syndrome
5) Alternative therapeutic approaches to prevent and cure Chagas disease

The long term goal of my laboratory group is to understand the interaction(s) of chronic infectious diseases and metabolic disorders to prevent the global burden of metabolic syndrome and cardiovascular disease. In addition to being interested in studying the pathogenesis Chagas disease, I am also interested in dissecting the link between adipose tissue physiology and pulmonary pathophysiology in Mycobacterium tuberculosis in the context of metabolic disorder.

The proposed work is supported by a NIH (NHLBI) RO1 award.






Selected Publications (out of 40)


Brima W, Eden DJ, Mehdi SF, Bravo M, Wiese MM, Stein J, Almonte V, Zhao D, Kurland I, Pessin JE, Zima T, Tanowitz HB, Weiss LM, Roth J, Nagajyothi F (2015) The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma cruzi infection in CD-1 mice. Diabetes Metab Res Rev 31: 346-359. PMI: 25613819

Wen JJ, Nagajyothi F, Machado FS, Weiss LM, Scherer PE, Tanowitz HB, Garg NJ (2014) Markers of oxidative stress in adipose tissue during Trypanosoma cruzi infection. Parasitol Res 113: 3159-3165. PMI: 24948102

Nagajyothi F, Weiss LM, Zhao D, Koba W, Jelicks LA, Cui MH, Factor SM, Scherer PE, Tanowitz HB (2014) High fat diet modulates Trypanosoma cruzi infection associated myocarditis. PLoS Negl Trop Dis 8: e3118. PMI: 25275627

Johndrow C, Nelson R, Tanowitz H, Weiss LM, Nagajyothi F (2014) Trypanosoma cruzi infection results in an increase in intracellular cholesterol. Microbes Infect 16: 337-344. PMI: 24486184

Burke S, Nagajyothi F, Thi MM, Hanani M, Scherer PE, Tanowitz HB, Spray DC (2014) Adipocytes in both brown and white adipose tissue of adult mice are functionally connected via gap junctions: implications for Chagas disease. Microbes Infect 16: 893-901. PMI: 25150689

Nagajyothi F, Kuliawat R, Kusminski CM, Machado FS, Desruisseaux MS, Zhao D, Schwartz GJ, Huang H, Albanese C, Lisanti MP, Singh R, Li F, Weiss LM, Factor SM, Pessin JE, Scherer PE, Tanowitz HB (2013) Alterations in glucose homeostasis in a murine model of Chagas disease. Am J Pathol 182: 886-894. PMI: 23321322

Nagajyothi F, Zhao D, Weiss LM, Tanowitz HB (2012) Curcumin treatment provides protection against Trypanosoma cruzi infection. Parasitol Res 110: 2491-2499. PMI: 22215192

Nagajyothi F, Desruisseaux MS, Machado FS, Upadhya R, Zhao D, Schwartz GJ, Teixeira MM, Albanese C, Lisanti MP, Chua SC, Jr., Weiss LM, Scherer PE, Tanowitz HB (2012) Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain). J Infect Dis 205: 830-840. PMI: 22293433

Nagajyothi F, Weiss LM, Silver DL, Desruisseaux MS, Scherer PE, Herz J, Tanowitz HB (2011) Trypanosoma cruzi utilizes the host low density lipoprotein receptor in invasion. PLoS Negl Trop Dis 5: e953. PMI: 21408103

Ferreira AV, Segatto M, Menezes Z, Macedo AM, Gelape C, de Oliveira Andrade L, Nagajyothi F, Scherer PE, Teixeira MM, Tanowitz HB (2011) Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease. Microbes Infect 13: 1002-1005. PMI: 21726660

Nagajyothi F, Desruisseaux MS, Thiruvur N, Weiss LM, Braunstein VL, Albanese C, Teixeira MM, de Almeida CJ, Lisanti MP, Scherer PE, Tanowitz HB (2008) Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype. Obesity (Silver Spring) 16: 1992-1997. PMI: 19186325








C.V.


Ph.D in Biochemistry, Mysore University, India 2001
Post-doc, Albert Einstein College of Medicine, NY 2001- 2007
Research Associate, Albert Einstein College of Medicine, NY 2007- 2010
Instructor, Albert Einstein College of Medicine, NY 2010- 2012
Assistant Professor, Albert Einstein College of Medicine, NY 2012- 2015
Assistant Professor, NJMS, PHRI, NJ Aug 2015

 
     Copyright © 2017 All rights reserved.   PHRI at ICPH 225 Warren St. Newark, NJ 07103-3535 TEL 973 854 3100, FAX 973 854 3101