Public Health Research Institute Center and
UMDNJ - New Jersey Medical School
225 Warren Street
Newark, New Jersey 07103

Phone: (973) 854-3262
e-mail: dubnaueu@umdnj.edu



Research Summary

Eugenie Dubnau (Jeanie) has been working in the field of Mycobacteria tuberculosis research since 1994. Her main interest has been in the area of lipid biosynthesis since she worked on mycolic acid biosynthesis in the laboratory of Dr. William Jacobs at the Albert Einstein College of Medicine. She was involved in the analysis of the target of isonaizid, a first line antitubercular antibiotic. Since that time, she has worked on various aspects of mycolic acid biosynthesis and now is interested in the regulation of genes required for the synthesis of these unusual lipids. She has also worked on gene expression of Mycobacteria tuberculosis during infection.

Jeanie Dubnau has recently become interested in the role of cholesterol metabolism in the virulence of Mycobacteria tuberculosis and has done work in collaboration with Dr. Nicole Sampson of the Chemistry Dept. in Stony Brook University.




Selected Publications


Xinxin Yang, Natasha M. Nesbitt, Eugenie Dubnau, Issar Smith and Nicole S. Sampson. (2009)
Cholesterol Metabolism Increases the Metabolic Pool of Propionate in M. tuberculosis.
Biochemistry 48: 3819-3821.

Xinxin Yang, Eugenie Dubnau, Issar Smith, and Nicole S. Sampson. (2007)
Rv1106c from Mycobacterium tuberculosis Is a 3-Hydroxysteroid Dehydrogenase.
Biochemistry 46: 9058-9067.

Shaun B. Walters, Eugenie Dubnau, Irina Kolesnikova, Francoise Laval, Mamadou Daffe and Issar Smith. (2006)
The Mycobacterium tuberculosis PhoPR Two Component System regulates genes important for virulence and complex lipid synthesis.
Mol. Microbiol. 60: 312-330.

Dubnau, E., Chen, J., Mohan, V.P., Smith, I. (2005)
Responses of Mycobacterium tuberculosis to Growth in the Mouse Lung.
Infection and Immunity 73: 3754-3757.

Dubnau, E., and Smith, I. (2003)
Mycobacterium tuberculosis gene expression in macrophages.
Microbes and Infection 5: 629-637.

Manganelli, R. Voskiul, M. I., Schoolnik, G.K., Dubnau, E., Gomez, M. and Smith, I. (2002)
Role of the Extracytoplasmic-Function Sigma factor Sigma H in Mycobacterium tuberculosis global gene expression.
Molecular Microbiology 45: 366 - 374.

Dubnau, E., Fontan, P., Manganelli, R., Soares-Appel, S. and Smith, I. (2002)
Identification of Mycobacterium tuberculosis genes induced during infection of human macrophages.
Infection and Immunity 70: 2787 - 2795.

Dubnau, E., Chan, J., Raynaud, C., Mohan, V.P., Lanelle, M.-A., Yu, K., Quemard A., Smith, I. and Daffe, M. (2000)
Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice.
Molecular Microbiology 36: 630 - 637.

Manganelli, R., Dubnau, E., Tyagi, S., Kramer, F. R. and Smith, I. (1999)
Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis.
Molecular Microbiology 31: 715 - 724.

Dubnau, E., Marrackchi, H., Smith, I., Daffe, M., and Quemard, A. (1998)
Mutations in the cmaB gene are responsible for the absence of methoxymycolic acid in Mycobacterium bovis BCG.
Molecular Microbiology 29: 1526 - 1528.

Smith, I., Dussurget, O., Rodriguez, G.M., Timm, J., Gomez, M., Dubnau, J., Gold, M. and Manganelli, R. (1998)
Extra-and intracellular expression of Mycobacterium tuberculosis genes.
Tubercule and Lung Disease 79: 91 - 978.

Dubnau, E., Laneelle, M.A., Soares, S., Benichou, A., Vaz, T., Prome, D., Prome, J.C. Daffe, M., Quemard, A. (1997)
Mycobacterium bovis, BCG genes involved in the biosynthesis of cycopropyl keto and hydroxy-mycolic acids.
Molec. Microbiol. 23: 313 - 322.

Dubnau, E., Soares, S., Huang, T., and Jacobs, W., (1996)
Overproduction of mycobacterial ribosomal protein S13 induces catalase peroxidase activity and hypersensitivity to isoniazid in Mycobacterium smegmatis.
Gene 170: 17 - 22.

Banerjee, A., Dubnau, E., Quemard, A., Balasubramanian, V., Um, K., Wilson, T., Collins, D., De Lisle, G., and Jacobs, W. (1994)
inhA, a Gene Encoding a Target for Isoniazid and Theionamide in Mycobacterium tuberculosis.
Science 263: 227 - 230.