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Public Health Research Institute Center and
UMDNJ - New Jersey Medical School
225 Warren Street
Newark, New Jersey 07103
Phone: (973) 854-3402
e-mail: dubnaueu@umdnj.edu
 Research Summary
Eugenie Dubnau (Jeanie) has been working together with Dr. David Dubnau, since March 2010. She is working on MecA, a protein which modulates the stationary phase processes of competence, sporulation and biofilm formation in Bacillus subtilis.
Selected Publications
Yang X, Gao J, Smith I, Dubnau E, Sampson NS (2011) Cholesterol is not an essential source of nutrition for Mycobacterium tuberculosis during infection. J Bacteriol 193: 1473-1476. PMI: 21257778
Nesbitt NM, Yang X, Fontan P, Kolesnikova I, Smith I, Sampson NS, Dubnau E (2010) A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol. Infect Immun 78: 275-282. PMI: 19822655
Yang X, Nesbitt NM, Dubnau E, Smith I, Sampson NS (2009) Cholesterol metabolism increases the metabolic pool of propionate in Mycobacterium tuberculosis. Biochemistry 48: 3819-3821. PMI: 19364125
Yang X, Dubnau E, Smith I, Sampson NS (2007) Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. Biochemistry 46: 9058-9067. PMI: 17630785
Walters SB, Dubnau E, Kolesnikova I, Laval F, Daffe M, Smith I (2006) The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol Microbiol 60: 312-330. PMI: 16573683
Dubnau E, Chan J, Mohan VP, Smith I (2005) responses of mycobacterium tuberculosis to growth in the mouse lung. Infect Immun 73: 3754-3757. PMI: 15908407
Dubnau E, Smith I (2003) Mycobacterium tuberculosis gene expression in macrophages. Microbes Infect 5: 629-637. PMI: 12787739
Manganelli R, Voskuil MI, Schoolnik GK, Dubnau E, Gomez M, Smith I (2002) Role of the extracytoplasmic-function sigma factor sigma(H) in Mycobacterium tuberculosis global gene expression. Mol Microbiol 45: 365-374. PMI: 12123450
Dubnau E, Fontan P, Manganelli R, Soares-Appel S, Smith I (2002) Mycobacterium tuberculosis genes induced during infection of human macrophages. Infect Immun 70: 2787-2795. PMI: 12010964
Dubnau E, Chan J, Raynaud C, Mohan VP, Laneelle MA, Yu K, Quemard A, Smith I, Daffe M (2000) Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice. Mol Microbiol 36: 630-637. PMI: 10844652
Manganelli R, Dubnau E, Tyagi S, Kramer FR, Smith I (1999) Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis. Mol Microbiol 31: 715-724. PMI: 10027986
Smith I, Dussurget O, Rodriguez GM, Timm J, Gomez M, Dubnau J, Gold B, Manganelli R (1998) Extra and intracellular expression of Mycobacterium tuberculosis genes. Tuber Lung Dis 79: 91-97. PMI: 10645446
Dubnau E, Marrakchi H, Smith I, Daffe M, Quemard A (1998) Mutations in the cmaB gene are responsible for the absence of methoxymycolic acid in Mycobacterium bovis BCG Pasteur. Mol Microbiol 29: 1526-1528. PMI: 9781890
Dubnau E, Laneelle MA, Soares S, Benichou A, Vaz T, Prome D, Prome JC, Daffe M, Quemard A (1997) Mycobacterium bovis BCG genes involved in the biosynthesis of cyclopropyl keto- and hydroxy-mycolic acids. Mol Microbiol 23: 313-322. PMI: 9044265
Dubnau E, Soares S, Huang TJ, Jacobs WR, Jr. (1996) Overproduction of mycobacterial ribosomal protein S13 induces catalase/peroxidase activity and hypersensitivity to isoniazid in Mycobacterium smegmatis. Gene 170: 17-22. PMI: 8621083
Banerjee A, Dubnau E, Quemard A, Balasubramanian V, Um KS, Wilson T, Collins D, de Lisle G, Jacobs WR, Jr. (1994) inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 263: 227-230. PMI: 8284673
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