Recent Articles

Low DE, Muller M, Duncan CL, Willey BM, de Azavedo JC, McGeer A, Kreiswirth BN, Pong-Porter S, Bast DJ.
Activity of BMS-284756, a novel des-fluoro(6) quinolone, against Staphylococcus aureus, including contributions of mutations to quinolone resistance.
Antimicrob Agents Chemother 2002 Apr;46(4):1119-21
PMID: 11897603

The in vitro activity of BMS-284756 against 602 Staphylococcus aureus isolates, including 152 that were both methicillin and ciprofloxacin resistant (MIC > or = 4 microg/ml), was determined. For ciprofloxacin-susceptible and nonsusceptible isolates, the MICs at which 50% of organisms were inhibited were 0.015 and 2 microg/ml and the MICs at which 90% of organisms were inhibited were 0.03 and 4 microg/ml, respectively.