PHRI :: Gilla Kaplan, Ph.D.

   Yuri Bushkin, Ph.D.
   Neeraj Chauhan, Ph.D.
   Loren Day, Ph.D.
   Karl Drlica, Ph.D.
   David Dubnau, Ph.D.
   Marila Gennaro, M.D.
   Gilla Kaplan, Ph.D.
   Fred Kramer, Ph.D.
   Barry Kreiswirth, Ph.D.
   Leonard Mindich, Ph.D.
   Arkady Mustaev, Ph.D.
   Harvey Penefsky, Ph.D.
   David Perlin, Ph.D.
   Richard Pine, Ph.D.
   Abraham Pinter, Ph.D.
   Issar Smith, Ph.D.
   Patricia Soteropoulos, Ph.D.
   Sanjay Tyagi, Ph.D.
   David Wah, Ph.D.
   Chaoyang Xue, Ph.D.

   Research Faculty
   Eugenie Dubnau, Ph.D.
   Patricia Fontán, Ph.D.
   Jeanette Hahn, Ph.D.
   Salvatore Marras, Ph.D.
   Marcela Rodriguez, Ph.D.
   Lisa K. Ryan, Ph.D.
   Xilin Zhao, Ph.D.

Gilla Kaplan, Ph.D.
	Recent Articles Manca C, Reed MB, Freeman S, Mathema B, Kreiswirth B, Barry CE 3rd, Kaplan G. (2004). *Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis* pathogenesis.** Infect Immun. 2004 Sep;72(9):5511-4 PMID: 15322056 In vitro infection of monocytes with Mycobacterium tuberculosis HN878 and related W/Beijing isolates preferentially induced interleukin-4 (IL-4) and IL-13, which characterize Th2 polarized immunity. In contrast, CDC1551 induced more IL-12 and other molecules associated with phagocyte activation and Th1 protective immunity. The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection.

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