Recent Articles

Shi L., North R, and Gennaro M.L. (2004).
Effect of growth state on transcription levels of genes encoding major secreted antigens of Mycobacterium tuberculosis in the mouse lung.
Infect Immun. 2004 Apr;72(4):2420-4
PMID: 15039373

Arrest of the multiplication of Mycobacterium tuberculosiscaused by expression of adaptive immunity in mouse lung was accompanied by a 10- to 20-fold decrease in levels of mRNAs encoding the secreted Ag85 complex and 38-kDa lipoprotein. esat-6 mRNA levels were high throughout infection. The data imply that multiplying and nonreplicating tubercle bacilli have different antigen compositions.