Recent Articles

Persuh M, Mandic-Mulec I, Dubnau, D.
A MecA paralog, YpbH, binds ClpC, affecting both competence and sporulation.
J Bacteriol 2002 Apr;184(8):2310-3
PMID: 11914365

ComK, the master regulator of competence, is degraded by the general stress-related protease ClpCP but must be targeted to this protease by binding to the adapter protein MecA. The genome of Bacillus subtilis contains a paralog of mecA, ypbH. We show in the present study that YpbH, like MecA, binds ClpC and that its elimination or overproduction affects competence and sporulation.