Recent Articles

Li X, Zhao X, Drlica K.
Selection of Streptococcus pneumoniae mutants having reduced susceptibility to
moxifloxacin and levofloxacin.
Antimicrob Agents Chemother 2002 Feb;46(2):522-4
PMID: 11796368

With Streptococcus pneumoniae, moxifloxacin was 4- and 10-fold more effective than levofloxacin at restricting selection of resistant mutants and at killing resistant mutants, respectively. The selection frequency for first-step topoisomerase mutants was 1,000 times lower for moxifloxacin than for levofloxacin; this difference was lost when second-step mutants were selected.