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 Recent Articles
Li X, Zhao X, Drlica K.
Selection of Streptococcus pneumoniae mutants having reduced
susceptibility to
moxifloxacin and levofloxacin.
Antimicrob Agents Chemother 2002 Feb;46(2):522-4
PMID: 11796368
With Streptococcus pneumoniae, moxifloxacin was 4- and 10-fold more
effective
than levofloxacin at restricting selection of resistant mutants
and at killing
resistant mutants, respectively. The selection frequency for first-step
topoisomerase mutants was 1,000 times lower for moxifloxacin than
for
levofloxacin; this difference was lost when second-step mutants
were selected.
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