Recent Articles

Dong, Y., Demaria, S., Sun, X., Santori, F.R., Jesdale, B,M., DeGroot, A., Rom, W.N. and Y Bushkin. (2004).
HLA-A2-restricted CD8+ cytotoxic T-cell responses to novel Mycobacterium tuberculosis targets superoxide dismutase, alanine dehydrogenase and glutamine sythetase.
Infect Immun. 2004 Apr;72(4):2412-5
PMID: 15039371

Major histocompatibility complex class I-restricted CD8⁺ cytotoxic T lymphocytes (CTL) are implicated in protective Th1 immunity to Mycobacterium tuberculosis infection. We report the identification of three novel HLA-A*0201-restricted CTL epitopes within mycobacterial superoxide dismutase (SodA), L-alanine dehydro-genase (AlaDH), and L-glutamine synthetase (GlnS) proteins.