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PHRI Scientist Receives 15.9 Million Dollar NIH Award
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We are extremely pleased to report that Dr. Abraham Pinter, a senior faculty member at PHRI,
has been awarded a five year $15.9 million grant from the National Institutes of Health's HIVRAD program (HIV Research and Development) to help develop a novel HIV vaccine platform.
In addition, PHRI is actively recruiting two other well funded HIV specialists to establish a cluster of excellence in HIV research at PHRI.
The basis for Dr. Pinter's vaccine strategy is the long-standing recognition that, unlike other types of viral infections,
infection with HIV fails to elicit a broadly protective antibody response. Thus, despite the production of high antibody titers in HIV-infected subjects,
these antibodies usually fail to neutralize typical viruses isolated from patients. Dr. Pinter's group has been studying the mechanisms for the resistance
of primary HIV isolates to neutralization by common antibodies, and has identified conformational masking of sensitive neutralization targets
as a major factor for this effect. These studies have identified a new class of 'quaternary' epitopes that are not susceptible to masking and are recognized by
antibodies present in some immune sera. These epitopes are dependent on the native trimeric surface protein structures of HIV. The goal of Dr. Pinter's
new program is to define the sequences and structure of this novel class of target, and to develop new vaccines that incorporate these antigens and are capable of inducing
related antibody activities.
This vaccine program involves a collaboration with several core laboratories at PHRI - NJMS along with researchers from three other institutions (Tulane University,
the University of Washington, and the NICD in South Africa).
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"Tuberculosis: The Continuing Challenge"
- A Celebration to Honor the Career of Dr. Lee Reichman
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On December 14, 2009, the Public Health Research Institute Center at the UMDNJ – New Jersey Medical School hosted a symposium to celebrate the career of Dr. Lee Reichman.
The symposium took place at the PHRI Center / UMDNJ – New Jersey Medical School.
Presentations were provided by
Gerald Friedland of Yale University Medical Center,
Philip C. Hopewell of the University of California at San Francisco,
Michael D. Iseman of the University of Colorado,
Wafaa El-Sadr of the Harlem Hospital,
Melvin Spigelman of the Global Alliance against TB, and
Kenneth Castro of the CDC.
The speakers have graciously agreed to publish their presentations and you may download the series of presentations in a single PDF file (size is 10.5 MB) by selecting the following link: Download Symposium Presentations
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 Employment Opportunities
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News & Noteworthy |
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11.02.09 |
Karl Drlica, PHRI faculty and member of the Department of Microbiology and Molecular Genetics,
was selected the 2009 Graduate School of Biomedical Sciences at the NJ Medical School ‘Mentor of the Year.’
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10.14.09 |
On October 14th, 2009, the PHRI Center organized its 7th Annual Summer High School Intern Program Symposium.
Please download the Symposium Announcement
for more details.
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Upcoming Seminar Series |
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