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"Bridging the Gap: Model Systems to Pathogens"
- A Celebration to Honor the Research Career of Dr. Issar Smith
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The Public Health Research Institute, together with the Emerging Infectious Diseases and Microbiology Discussion Group,
had the privilege to organize a symposium to celebrate the career of Dr. Issar Smith (Smitty).
Dr. Smith has spent over 42 years at the Public Health Research Institute studying the control of sporulation and gene
regulation in Bacillus subtilis and pathogenesis in Mycobacterium tuberculosis.
The event took place on December 10, 2008, at the New York Academy of Sciences.
Presentations were given by Stanley Falkow of Stanford University, David Dubnau of the PHRI,
Richard M. Losick of Harvard College, Brigitte Gicquel of Institut Pasteur, David Russell of Cornell University,
and Michael D. Iseman of the University of Colorado. The presentations were followed by a reception in honor of Dr. Smith.
For more details on this symposium and other events at the New York Academy of Sciences, please visit the Academy's web site.
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Paper Highlight |
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The Mycobacterium tuberculosis transcription factor sigma E regulates expression of several bacterial components, including those that maintain the cell envelope and others that enable it to respond to environmental stresses. Sigma E is also essential for M. tuberculosis survival in macrophages and in the lungs of infected animals. Recent work, discussed by PHRI scientists Patricia Fontán and Issar Smith in the accompanying review, indicate that several bacterial genes are not expressed when the sigma E mutant strain infects macrophage infections and also that the products of these genes in the wild type bacterium suppress host innate immune responses. Further, these results suggest that the M. tuberculosis sigma E mutant, because it elicits elevated immune responses during infections, could serve as an effective live, attenuated vaccine strain. This review, "M. tuberculosis Sigma E protects against environmental stress, immune responses", was published in Microbe, Volume 4, Number 3, 2009, pages 119-123.
To download a copy of this publication, please follow this link
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 Employment Opportunities
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News & Noteworthy |
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12.11.08 |
Special Acknowledgement - New Jersey's Top 10 Scientists
PHRI is proud to announce that New Jersey Business magazine, in cooperation with Technology-based Trade Associations in New Jersey,
has recognized PHRI Scientist Dr. Fred Russell Kramer as one of the Top 10 New Jersey Scientists.
In their December 2008 issue, Fred Kramer, together with the other selected Top 10 scientists, will be featured,
describing their innovative contributions to science and society.
Please follow this link to download a pdf copy of the New Jersey Business
magazine’s story on "NJ's Top 10 Scientists
- Special Recognition." For a description of Fred Kramer’s research interest and biography,
please visit
this link.
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