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January 15, 2010
Postdoctoral and Research Associate positions available in the Department of Medicine/Public Health Research Institute, UMDNJ, Newark NJ.
Principal Investigator: Dr. Abraham Pinter
E-Mail: pinterab@umdnj.edu
Research Project:
With the inability of available HIV-1 vaccines to achieve protection, there is a clear need for the identification of novel vaccine targets and approaches. Our approach to address this problem is based on the identification of antibodies in sera of HIV-infected subjects that possess broad and potent neutralizing activities. The nature of the targets of these antibodies is not known, but evidence suggests that these do not represent standard well-characterized epitopes, and in some cases, involve quaternary targets that are dependent on the native trimeric Env structure. Our program involves screening immune sera for such activities, characterizing the antibodies and epitopes that are involved, cloning monoclonal antibodies that possess similar activities, and designing immunogens and vaccination strategies for inducing such broadly protective antibody responses.
We are located in an attractive section of Newark, NJ, readily accessible from New York City and residential neighborhoods in North and South New Jersey.
Qualifications:
Highly motivated and ambitious scientists who are technically skilled and imaginative. Experience required in the areas of HIV-1 immunology, viral neutralization assays, molecular cloning and site-specific mutagenesis, Env protein expression and characterization, and monoclonal antibody cloning and characterization. Good writing skills and familiarity with relevant literature are major advantages.
For more information on Dr. Pinter's laboratory, please visit his web site.
Candidates should submit their curriculum vitae, a statement of current and future research interests and email addresses of three references to pinterab@umdnj.edu
October 1, 2009
Faculty Positions in Fundamental and Applied Infectious Diseases Research at the PHRI Center
The PHRI Center of the University of Medicine and Dentistry of New Jersey - New Jersey Medical School, located in Newark, New Jersey, is recruiting
a new faculty member at the middle or senior level to join a growing group of 19 laboratories. PHRI is a leading infectious diseases research center
with a strong commitment to basic science. Candidates must have training and experience of the highest quality and a NIH funded research program
addressing fundamental questions in cell biology, immunology, molecular biology, or structural biology. We are especially interested in candidates
who are studying host:pathogen interactions. The PHRI Center is housed in a state of the art building that has extensive core services,
including animal facilities, BL3 laboratories, X-ray facility for structural studies and applied genomics center. The PHRI Center offers
a robust and highly collegial research environment, generous start-up funds, and a comprehensive benefits package.
Candidates should submit curriculum vitae, a statement of research interests and accomplishments, and a list of at least three references.
Any questions or applications should be sent to:
Dr. Issar Smith
Recruitment Committee
Public Health Research Institute Center
UMDNJ - New Jersey Medical School
225 Warren Street
Newark, NJ 07103
Telephone (973) 854-3260
Email: smithis@umdnj.edu
September 30, 2009
Postdoctoral Research Associate Positions
Post doctoral research positions are available for study at PHRI, as follows:
The Perlin Laboratory: The Perlin lab is interested in mechanisms of antifungal drugs resistance, rapid detection
and susceptibility of invasive fungal pathogens in high-risk patients, and the development of small animal models for bacterial
and fungal respiratory pathogens. Two postodoctoral positions are available to study mechanisms of antifungal drug resistance
and the mechanistic behavior of the antiarrhythmic drug amiodarone. 1) The echinocandin antifungal drugs target the fungal
cell wall by blocking β-(1,3)-D-glucan synthase. Recently, we reported that amino acid substitutions in two regions of Fks1p,
a primary component of the glucan synthase complex, could account for resistance in laboratory and clinical isolates of
Candida albicans and Aspergillus fumigatus. The objective of this program is to explore in detail by genetic and biochemical
means the role of Fks1p as an important new mechanism for clinical resistance to echinocandin drugs; 2) the antiarrhythmic
drug amiodarone has antifungal properties resulting from an effect on calcium homeostasis. The objective of this work is
to explore with pathogenic fungi the synergistic behavior of amiodarone with other antifungal drugs.
For more information on Dr. Perlin's laboratory, please visit his web site.
Please email curriculum vitae, reprints of publications and names of three references to Dr. David S. Perlin
Dr. David S. Perlin
Public Health Research Institute Center
UMDNJ - New Jersey Medical School
225 Warren Street
Newark, NJ 07103
Telephone (973) 854-3200
Email: perlinds@umdnj.edu
The Pinter Laboratory: The Pinter lab is characterizing the neutralizing components of the humoral immune response
against HIV-1 Env and developing new approaches towards an effective HIV-1 vaccine. Post-doctoral research positions are available
for recent PhDs with experience in HIV-1 virology and immunology, including the isolation of monoclonal antibodies and the cloning of
Env and immunoglobulin genes. The ideal candidate should be highly motivated and able to work independently. US citizenship or
green card status preferred.
For more information on Dr. Pinter's laboratory, please visit his web site.
Please email curriculum vitae, reprints of publications and names of three references to Dr. Abraham Pinter
Dr. Abraham Pinter
Public Health Research Institute Center
UMDNJ - New Jersey Medical School
225 Warren Street
Newark, NJ 07103
Telephone (973) 854-3300
Email: pinterab@umdnj.edu
September 24, 2009
Two positions are available at the Public Health Research Institute at UMDNJ, New Jersey Medical School, in the laboratory of Dr. Yuri Bushkin.
1. Molecular Immunology of Antigen Cross-Presentation
2. Novel Vaccines against Tuberculosis in Mouse Model.
1. A post-doctoral position is available to study novel pathways of antigen cross-presentation mediated by ADAMs and regulated by cytokines. Excellent skills in molecular biology, proficiency in construction of chimeric proteins and track record of siRNA work in mammalian cells are critical. Experience in tissue culture, basic protein chemistry techniques and cellular immunology is essential.
2. A post-doctoral or laboratory technician position is available to assist in the development of novel vaccines against Mycobacterium tuberculosis in a mouse model. Ability to work in BSL-3 and ABSL-3 facilities is required. Experience in small animal surgery, mouse handling, basic microbiological and immunological techniques is critical. Excellent organizational skills are essential.
For more information on Dr. Bushkin's laboratory, please visit his web site.
Eligible candidates must be in the US. Motivated candidates with good interpersonal and communication skills are encouraged to apply. Please provide a cover letter explaining relevant work experience, curriculum vitae and the names, telephone numbers and e-mail addresses of three referees by e-mail. Contact by e-mail or phone and be available for an interview.
Dr. Yuri Bushkin
Adjunct Professor
Public Health Research Institute Center
Department of Medicine
UMDNJ - New Jersey Medical School
225 Warren Street
Newark, NJ 07103
Email: bushkiyu@umndj.edu
Tel. (973) 854-3350
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