Overview Research Programs News & Outreach Technology Transfer About PHRI

 
 
 

"Tuberculosis: The Continuing Challenge"
- A Celebration to Honor the Career of Dr. Lee Reichman

 

On December 14, 2009, the Public Health Research Institute Center at the UMDNJ – New Jersey Medical School hosted a symposium to celebrate the career of Dr. Lee Reichman.

The symposium took place at the PHRI Center / UMDNJ – New Jersey Medical School. Presentations were provided by Gerald Friedland of Yale University Medical Center, Philip C. Hopewell of the University of California at San Francisco, Michael D. Iseman of the University of Colorado, Wafaa El-Sadr of the Harlem Hospital, Melvin Spigelman of the Global Alliance against TB, and Kenneth Castro of the CDC.

The speakers have graciously agreed to publish their presentations and you may download the series of presentations in a single PDF file (size is 10.5 MB) by selecting the following link: Download Symposium Presentations



Paper Highlight

 
The first structure solved using data obtained from the PHRI X-ray Crystallography Core Facility was published in the Proceedings of the National Academy of Sciences. The laboratory of Dr. David Wah solved the structure of the C-terminal domain of Transcription Factor IIB (TFIIB) from the infectious parasite Trypanosoma brucei, the causative agent of African Sleeping sickness. T. brucei TFIIB is essential for the viability of this parasite. Strikingly, the putative DNA binding surface of T. brucei is different from the DNA binding surface of human TFIIB, suggesting that T. brucei TFIIB binds DNA in a different way from human TFIIB. These results give insights into transcriptional regulation in trypanosomes. A more thorough mechanistic understanding of the trypanosome transcriptional machinery will allow us to develop new therapeutic tools against these parasites. The results are published in Proc Natl Acad Sci USA 2009, Volume 106, Number 32, pages 13242-13247.

To download a copy of this publication, please follow this link


   
   

Employment Opportunities


  01.15.10   Postdoctoral and Research Associate Positions Available
click here for details
    
  10.01.09   Faculty Positions in Fundamental and Applied Infectious Diseases Research Available
click here for details
    
  10.01.09   Postdoctoral Positions Available
click here for details
    
  10.01.09   Laboratory Technician Position Available
click here for details
    
    

News & Noteworthy


  11.02.09   Karl Drlica, PHRI faculty and member of the Department of Microbiology and Molecular Genetics, was selected the 2009 Graduate School of Biomedical Sciences at the NJ Medical School ‘Mentor of the Year.’
    
  10.14.09   On October 14th, 2009, the PHRI Center organizinged its 7th Annual Summer High School Intern Program Symposium. Please download the Symposium Announcement for more details.
    
    

Upcoming Seminar Series


  02.02.10   Thomas J. Kelly , Sloan-Kettering Institute
DNA Replication in S. pombe
click here for more information
    
  02.09.10   Bin Tian, UMDNJ-NJMS
Alternative Polyadenylation in Development: Logic and Logistics
click here for more information
    
  02.16.10   George S. Yap , UMDNJ-NJMS
Immunology of Parasite Infections
click here for more information
    
  02.23.10   Kathleen A. McDonough, Wadsworth Cente
cAMP signaling and Gene Regulation in Mycobacterium tuberculosis: Old Molecule, New Venues
click here for more information
    




     Copyright © 2010 All rights reserved.   PHRI at ICPH 225 Warren St. Newark, NJ 07103-3535 TEL 973 854 3100, FAX 973 854 3101